{"entity":{"id":"sdhd","kind":"target","name":"SDHD","aka":["succinate dehydrogenase complex subunit D","Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial","cybS","PGL1"],"tldr":"SDHD (Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.","summary":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.96, genetic literature 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10683"},{"label":"UniProt O14521","url":"https://www.uniprot.org/uniprotkb/O14521/entry"},{"label":"NCBI Gene 6392","url":"https://www.ncbi.nlm.nih.gov/gene/6392"},{"label":"Ensembl ENSG00000204370","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204370"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SDHD","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10683","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10683","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14521","url":"https://www.uniprot.org/uniprotkb/O14521/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000204370","url":"https://platform.opentargets.org/target/ENSG00000204370/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.87 (GraphQL API, CC0)"}],"hgnc":"HGNC:10683","ensembl":"ENSG00000204370","uniprot":"O14521","entrez":"6392","biology":"Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidises malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerised into keto-oxaloacetate. Location: Mitochondrion inner membrane (UniProt). Locus 11q23.1 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.87 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"other","prevalence":[]},"route":"/targets/sdhd/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}