{"entity":{"id":"serrated-polyposis-syndrome","kind":"term","name":"Serrated polyposis syndrome","aka":["hyperplastic polyposis syndrome","serrated polyposis"],"tldr":"Serrated polyposis syndrome means having many serrated polyps in the bowel, a type that can turn into cancer, and it raises bowel cancer risk for the person and their close relatives. Clearing the polyps and then yearly colonoscopy is recommended, and close relatives are offered a colonoscopy at 40.","summary":"Diagnosed on the WHO 2019 criteria; no single causative gene has been found and inheritance is not Mendelian, though first-degree relatives have a raised colorectal cancer risk and rare RNF43 and GREM1 variants are reported. It overlaps with MUTYH-associated polyposis, hereditary mixed polyposis and attenuated FAP, which have to be excluded. Prevalence reached 1 in 100 in one FIT-based screening cohort.\n\nBSG 2020: yearly colonoscopy once all lesions over 5 mm are cleared, extending to two-yearly if no polyp of 10 mm or more is found (strong recommendation); first-degree relatives offered colonoscopy at 40 or ten years before the index case's diagnosis, then five-yearly. With this surveillance at academic centres, colorectal cancer was diagnosed at 1.9 per 1,000 patient-years of follow-up.","asOf":"2026-11-04","wikipedia":"https://en.wikipedia.org/wiki/Serrated_polyposis_syndrome","links":[{"label":"Monahan, Gut 2020: BSG, ACPGBI and UKCGG guidelines for the management of hereditary colorectal cancer","url":"https://doi.org/10.1136/gutjnl-2019-319915"},{"label":"Orphanet ORPHA:157798","url":"https://www.orpha.net/en/disease/detail/157798"}],"tags":["gap-fill","hereditary"],"related":[],"cancers":["colorectal","colorectal-serrated-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["serrated-pathway","colonoscopy","colonoscopy-surveillance-intervals","hereditary-cancer-syndromes"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Orphanet ORPHA:157798, listed in the inherited digestive cancer-predisposing branch. Recorded with the hereditary syndromes because of the family risk, not because a gene is known."],"category":"Genomics & genetics"},"route":"/terms/serrated-polyposis-syndrome/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"colorectal-serrated-adenocarcinoma","kind":"cancer","name":"Serrated adenocarcinoma of the colon and rectum","route":"/cancers/colorectal-serrated-adenocarcinoma/"}],"term":[{"id":"colonoscopy","kind":"term","name":"Colonoscopy","route":"/terms/colonoscopy/"},{"id":"hereditary-cancer-syndromes","kind":"term","name":"Hereditary cancer syndromes","route":"/terms/hereditary-cancer-syndromes/"},{"id":"serrated-pathway","kind":"term","name":"Serrated pathway","route":"/terms/serrated-pathway/"},{"id":"colonoscopy-surveillance-intervals","kind":"term","name":"Surveillance intervals after polypectomy","route":"/terms/colonoscopy-surveillance-intervals/"}]}}