{"entity":{"id":"set","kind":"target","name":"SET","aka":["SET nuclear proto-oncogene","PHAPII","2PP2A","IPP2A2","TAF-IBETA","IGAAD","TAF-I"],"tldr":"SET (SET nuclear proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Non-Hodgkin lymphoma and Acute lymphoblastic leukaemia.","summary":"Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.\n\nOpen Targets scores its association with cancer at 0.46 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.59).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10760","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10760"},{"label":"UniProt Q01105","url":"https://www.uniprot.org/uniprotkb/Q01105/entry"},{"label":"NCBI Gene 6418","url":"https://www.ncbi.nlm.nih.gov/gene/6418"},{"label":"Ensembl ENSG00000119335","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119335"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SET","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10760","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10760","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q01105","url":"https://www.uniprot.org/uniprotkb/Q01105/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000119335","url":"https://platform.opentargets.org/target/ENSG00000119335/associations","note":"association with cancer (MONDO_0004992) 0.46; per-cancer scores at or above 0.5: acute lymphoblastic leukaemia 0.52, non-Hodgkin lymphoma 0.54, leukaemia 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:10760","ensembl":"ENSG00000119335","uniprot":"Q01105","entrez":"6418","biology":"Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. Location: Cytoplasm, cytosol; Endoplasmic reticulum; Nucleus, nucleoplasm (UniProt). Locus 9q34.11 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.55 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.52 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"other","prevalence":[]},"route":"/targets/set/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}