{"entity":{"id":"setbp1","kind":"target","name":"SETBP1","aka":["SET binding protein 1","SET-binding protein","KIAA0437"],"tldr":"SETBP1 (SET-binding protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Breast cancer and 5 more.","summary":"UniProt has no function text for Q9Y6X0; HGNC names it \"SET binding protein 1\".\n\nCIViC holds 3 clinical evidence items and 0 assertions across 3 variants. Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.83, somatic mutation 0.84, genetic literature 0.83). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adrenocortical Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15573","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15573"},{"label":"UniProt Q9Y6X0","url":"https://www.uniprot.org/uniprotkb/Q9Y6X0/entry"},{"label":"NCBI Gene 26040","url":"https://www.ncbi.nlm.nih.gov/gene/26040"},{"label":"Ensembl ENSG00000152217","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000152217"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["myeloproliferative-neoplasms","leukaemia","breast-cancer","mds","adrenocortical","skin-cancer","lung-cancer","neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Juvenile Myelomonocytic Leukaemia; Atypical Chronic Myeloid Leukaemia, BCR-ABL1 Negative."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SETBP1","role":["oncogene-driver","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:15573","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15573","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6X0","url":"https://www.uniprot.org/uniprotkb/Q9Y6X0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SETBP1","url":"https://civicdb.org/features/10024","note":"3 evidence items, 0 assertions, 3 variants; diseases: Chronic Myeloid Leukaemia, Juvenile Myelomonocytic Leukaemia, Atypical Chronic Myeloid Leukaemia, BCR-ABL1 Negative (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000152217","url":"https://platform.opentargets.org/target/ENSG00000152217/associations","note":"association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.51, gastric cancer 0.51, melanoma 0.57, neuroendocrine neoplasm 0.52, acute myeloid leukaemia 0.67, skin cancer 0.57 (GraphQL API, CC0)"},{"label":"IntOGen SETBP1","url":"https://www.intogen.org/search?gene=SETBP1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:15573","ensembl":"ENSG00000152217","uniprot":"Q9Y6X0","entrez":"26040","biology":"UniProt has no function text for Q9Y6X0; HGNC names it \"SET binding protein 1\". Location: Nucleus (UniProt). Locus 18q12.3 (HGNC).","whereFound":["Myeloproliferative neoplasms: Open Targets association 0.77 with myeloproliferative neoplasm (MONDO_0020076)","Leukaemia: Open Targets association 0.77 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254)","Myelodysplastic syndromes / neoplasms: Open Targets association 0.66 with myelodysplastic syndrome (MONDO_0018881)","Adrenocortical carcinoma: IntOGen driver in 1 cohort (ACC)","Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/setbp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adrenocortical","kind":"cancer","name":"Adrenocortical carcinoma","route":"/cancers/adrenocortical/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}