{"entity":{"id":"sfpq","kind":"target","name":"SFPQ","aka":["splicing factor proline and glutamine rich","Splicing factor, proline- and glutamine-rich","PPP1R140"],"tldr":"SFPQ (Splicing factor, proline- and glutamine-rich) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner and a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.00, somatic mutation 0.89).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10774","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10774"},{"label":"UniProt P23246","url":"https://www.uniprot.org/uniprotkb/P23246/entry"},{"label":"NCBI Gene 6421","url":"https://www.ncbi.nlm.nih.gov/gene/6421"},{"label":"Ensembl ENSG00000116560","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116560"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene; UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SFPQ","role":["fusion-partner","dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10774","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10774","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23246","url":"https://www.uniprot.org/uniprotkb/P23246/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000116560","url":"https://platform.opentargets.org/target/ENSG00000116560/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10774","ensembl":"ENSG00000116560","uniprot":"P23246","entrez":"6421","biology":"DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Location: Nucleus speckle; Nucleus matrix; Cytoplasm (UniProt). Locus 1p34.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/sfpq/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}