{"entity":{"id":"sfrp4","kind":"target","name":"SFRP4","aka":["secreted frizzled related protein 4","Secreted frizzled-related protein 4","frpHE","FRP-4","FRPHE","FRZB-2"],"tldr":"SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.","summary":"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, animal model 0.54, genetic association 0.14, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10778","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10778"},{"label":"UniProt Q6FHJ7","url":"https://www.uniprot.org/uniprotkb/Q6FHJ7/entry"},{"label":"NCBI Gene 6424","url":"https://www.ncbi.nlm.nih.gov/gene/6424"},{"label":"Ensembl ENSG00000106483","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106483"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","gastric","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SFRP4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10778","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10778","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6FHJ7","url":"https://www.uniprot.org/uniprotkb/Q6FHJ7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000106483","url":"https://platform.opentargets.org/target/ENSG00000106483/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: colorectal cancer 0.54, gastric cancer 0.52, skin cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:10778","ensembl":"ENSG00000106483","uniprot":"Q6FHJ7","entrez":"6424","biology":"Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signalling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Location: Secreted (UniProt). Locus 7p14.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)"],"targetClass":"other","prevalence":[]},"route":"/targets/sfrp4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}