{"entity":{"id":"sh3gl1","kind":"target","name":"SH3GL1","aka":["SH3 domain containing GRB2 like 1, endophilin A2","Endophilin-A2","SH3P8","SH3D2B","CNSA1","MGC111371"],"tldr":"SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.01, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10830","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10830"},{"label":"UniProt Q99961","url":"https://www.uniprot.org/uniprotkb/Q99961/entry"},{"label":"NCBI Gene 6455","url":"https://www.ncbi.nlm.nih.gov/gene/6455"},{"label":"Ensembl ENSG00000141985","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141985"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SH3GL1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10830","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10830","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99961","url":"https://www.uniprot.org/uniprotkb/Q99961/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141985","url":"https://platform.opentargets.org/target/ENSG00000141985/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10830","ensembl":"ENSG00000141985","uniprot":"Q99961","entrez":"6455","biology":"Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Location: Cytoplasm; Early endosome membrane; Cell projection, podosome (UniProt). Locus 19p13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sh3gl1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}