{"entity":{"id":"shtn1","kind":"target","name":"SHTN1","aka":["shootin 1","Shootin-1","shootin1","shootin-1","KIAA1598"],"tldr":"SHTN1 (Shootin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.","summary":"Involved in the generation of internal asymmetric signals required for neuronal polarisation and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signalling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organisation by regulating the subcellular localisation of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29319","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29319"},{"label":"UniProt A0MZ66","url":"https://www.uniprot.org/uniprotkb/A0MZ66/entry"},{"label":"NCBI Gene 57698","url":"https://www.ncbi.nlm.nih.gov/gene/57698"},{"label":"Ensembl ENSG00000187164","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187164"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SHTN1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29319","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29319","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A0MZ66","url":"https://www.uniprot.org/uniprotkb/A0MZ66/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SHTN1","url":"https://www.intogen.org/search?gene=SHTN1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29319","ensembl":"ENSG00000187164","uniprot":"A0MZ66","entrez":"57698","biology":"Involved in the generation of internal asymmetric signals required for neuronal polarisation and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signalling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organisation by regulating the subcellular localisation of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. Location: Perikaryon; Cell projection, axon; Cell projection, growth cone; Cytoplasm, cytoskeleton (UniProt). Locus 10q25.3 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/shtn1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}