{"entity":{"id":"sidt1","kind":"target","name":"SIDT1","aka":["SID1 transmembrane family member 1","FLJ20174","SID-1"],"tldr":"SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.65).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25967"},{"label":"UniProt Q9NXL6","url":"https://www.uniprot.org/uniprotkb/Q9NXL6/entry"},{"label":"NCBI Gene 54847","url":"https://www.ncbi.nlm.nih.gov/gene/54847"},{"label":"Ensembl ENSG00000072858","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072858"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SIDT1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:25967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25967","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NXL6","url":"https://www.uniprot.org/uniprotkb/Q9NXL6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000072858","url":"https://platform.opentargets.org/target/ENSG00000072858/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:25967","ensembl":"ENSG00000072858","uniprot":"Q9NXL6","entrez":"54847","biology":"In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Location: Membrane (UniProt). Locus 3q13.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sidt1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}