{"entity":{"id":"siglec10","kind":"target","name":"Siglec-10","aka":["SIGLEC-10","sialic acid binding Ig like lectin 10","SLG2"],"tldr":"Siglec-10 is the receptor on macrophages and other blood cells that reads the CD24 'don't eat me' badge on tumour cells and calls off the attack.","summary":"SIGLEC10 (chromosome 19q13.41) is a sialic-acid-binding immunoglobulin-like lectin that preferentially binds alpha-2,3- or alpha-2,6-linked sialic acid and seems to act as an inhibitory receptor in the immune response, recruiting cytoplasmic phosphatases through its ITIMs on ligand-induced phosphorylation; it is expressed by peripheral blood leukocytes (eosinophils, monocytes and an NK-cell subpopulation) and in lymph node, lung, ovary and appendix (UniProt Q96LC7). The CD24-Siglec-10 interaction inhibits macrophage phagocytosis and NK cytotoxicity (Panagiotou et al. 2022).","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:15620","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15620"},{"label":"UniProt Q96LC7","url":"https://www.uniprot.org/uniprotkb/Q96LC7/entry"},{"label":"NCBI Gene 89790","url":"https://www.ncbi.nlm.nih.gov/gene/89790"}],"tags":["checkpoint-map"],"related":["cd24","sirpa","macrophage"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cancer-immunity-cycle"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Prevalence not recorded: HGNC and UniProt carry no positivity rates."],"provenance":{"editedBy":"OnCo checkpoint map (HGNC REST, UniProt REST, ClinicalTrials.gov v2)","editedOn":"2026-09-24"},"symbol":"SIGLEC10","role":["immune-checkpoint"],"sources":[{"label":"HGNC HGNC:15620","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15620","note":"approved symbol, name, aliases and cross-references"},{"label":"UniProt Q96LC7","url":"https://www.uniprot.org/uniprotkb/Q96LC7/entry","note":"protein name, function and tissue specificity"}],"specificitySources":[],"hgnc":"HGNC:15620","ensembl":"ENSG00000142512","uniprot":"Q96LC7","entrez":"89790","biology":"An ITIM-bearing Siglec; the receptor half of the CD24 pair.","whereFound":["Eosinophils, monocytes, an NK subpopulation (UniProt Q96LC7)"],"targetClass":"checkpoint","prevalence":[]},"route":"/targets/siglec10/","neighbours":{"target":[{"id":"cd24","kind":"target","name":"CD24","route":"/targets/cd24/"},{"id":"sirpa","kind":"target","name":"SIRPA","route":"/targets/sirpa/"}],"term":[{"id":"checkpoint","kind":"term","name":"Checkpoint (two meanings)","route":"/terms/checkpoint/"},{"id":"macrophage","kind":"term","name":"Macrophage","route":"/terms/macrophage/"}],"pathway":[{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}]}}