{"entity":{"id":"sim2","kind":"target","name":"SIM2","aka":["SIM bHLH transcription factor 2","Single-minded homolog 2","MGC119447","bHLHe15"],"tldr":"SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.40, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10883","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10883"},{"label":"UniProt Q14190","url":"https://www.uniprot.org/uniprotkb/Q14190/entry"},{"label":"NCBI Gene 6493","url":"https://www.ncbi.nlm.nih.gov/gene/6493"},{"label":"Ensembl ENSG00000159263","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159263"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SIM2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10883","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10883","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14190","url":"https://www.uniprot.org/uniprotkb/Q14190/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000159263","url":"https://platform.opentargets.org/target/ENSG00000159263/associations","note":"association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:10883","ensembl":"ENSG00000159263","uniprot":"Q14190","entrez":"6493","biology":"Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Location: Nucleus (UniProt). Locus 21q22.13 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/sim2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}