{"entity":{"id":"six1","kind":"target","name":"SIX1","aka":["SIX homeobox 1","Homeobox protein SIX1","DFNA23"],"tldr":"SIX1 (Homeobox protein SIX1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer and Wilms tumour.","summary":"Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as a transcriptional repressor or activator.\n\nOpen Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.99, animal model 0.49, genetic association 0.51, somatic mutation 0.89). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Wilms' Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10887","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10887"},{"label":"UniProt Q15475","url":"https://www.uniprot.org/uniprotkb/Q15475/entry"},{"label":"NCBI Gene 6495","url":"https://www.ncbi.nlm.nih.gov/gene/6495"},{"label":"Ensembl ENSG00000126778","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126778"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["colorectal","wilms-tumor"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SIX1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10887","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10887","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15475","url":"https://www.uniprot.org/uniprotkb/Q15475/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126778","url":"https://platform.opentargets.org/target/ENSG00000126778/associations","note":"association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0)"},{"label":"IntOGen SIX1","url":"https://www.intogen.org/search?gene=SIX1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10887","ensembl":"ENSG00000126778","uniprot":"Q15475","entrez":"6495","biology":"Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as a transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer. Location: Nucleus; Cytoplasm (UniProt). Locus 14q23.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Wilms tumour: IntOGen driver in 1 cohort (WT)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/six1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"wilms-tumor","kind":"cancer","name":"Wilms tumour (nephroblastoma)","route":"/cancers/wilms-tumor/"}]}}