{"entity":{"id":"skil","kind":"target","name":"SKIL","aka":["SKI like proto-oncogene","Ski-like protein","SnoN","SnoA"],"tldr":"SKIL (Ski-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"May have regulatory role in cell division or differentiation in response to extracellular signals.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.95, animal model 0.37, genetic association 0.62, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10897","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10897"},{"label":"UniProt P12757","url":"https://www.uniprot.org/uniprotkb/P12757/entry"},{"label":"NCBI Gene 6498","url":"https://www.ncbi.nlm.nih.gov/gene/6498"},{"label":"Ensembl ENSG00000136603","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000136603"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SKIL","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10897","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10897","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P12757","url":"https://www.uniprot.org/uniprotkb/P12757/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000136603","url":"https://platform.opentargets.org/target/ENSG00000136603/associations","note":"association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:10897","ensembl":"ENSG00000136603","uniprot":"P12757","entrez":"6498","biology":"May have regulatory role in cell division or differentiation in response to extracellular signals. Locus 3q26.2 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/skil/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}