{"entity":{"id":"skp1","kind":"target","name":"SKP1","aka":["S-phase kinase associated protein 1","S-phase kinase-associated protein 1","EMC19","OCP2","TCEB1L","MGC34403","OCP-II","p19A","SKP1A"],"tldr":"SKP1 (S-phase kinase-associated protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.83, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10899","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10899"},{"label":"UniProt P63208","url":"https://www.uniprot.org/uniprotkb/P63208/entry"},{"label":"NCBI Gene 6500","url":"https://www.ncbi.nlm.nih.gov/gene/6500"},{"label":"Ensembl ENSG00000113558","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113558"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SKP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10899","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10899","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P63208","url":"https://www.uniprot.org/uniprotkb/P63208/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113558","url":"https://platform.opentargets.org/target/ENSG00000113558/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10899","ensembl":"ENSG00000113558","uniprot":"P63208","entrez":"6500","biology":"Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signalling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. Locus 5q31.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/skp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}