{"entity":{"id":"slc12a2","kind":"target","name":"SLC12A2","aka":["solute carrier family 12 member 2","Solute carrier family 12 member 2","NKCC1","BSC2","BSC-2","PPP1R141","CCC1"],"tldr":"SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.","summary":"Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Temozolomide and Antisecretory Factor-enriched Egg Yolk Powder Supplement.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10911","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10911"},{"label":"UniProt P55011","url":"https://www.uniprot.org/uniprotkb/P55011/entry"},{"label":"NCBI Gene 6558","url":"https://www.ncbi.nlm.nih.gov/gene/6558"},{"label":"Ensembl ENSG00000064651","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064651"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC12A2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10911","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10911","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55011","url":"https://www.uniprot.org/uniprotkb/P55011/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SLC12A2","url":"https://civicdb.org/features/5323","note":"2 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0)"}],"hgnc":"HGNC:10911","ensembl":"ENSG00000064651","uniprot":"P55011","entrez":"6558","biology":"Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Location: Basolateral cell membrane (UniProt). Locus 5q23.3 (HGNC).","whereFound":["Glioma & glioblastoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/slc12a2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}]}}