{"entity":{"id":"slc14a1","kind":"target","name":"SLC14A1","aka":["solute carrier family 14 member 1 (Kidd blood group)","Urea transporter 1","HsT1341","RACH1","RACH2"],"tldr":"SLC14A1 (Urea transporter 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, animal model 0.29, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10918","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10918"},{"label":"UniProt Q13336","url":"https://www.uniprot.org/uniprotkb/Q13336/entry"},{"label":"NCBI Gene 6563","url":"https://www.ncbi.nlm.nih.gov/gene/6563"},{"label":"Ensembl ENSG00000141469","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141469"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC14A1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10918","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10918","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13336","url":"https://www.uniprot.org/uniprotkb/Q13336/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141469","url":"https://platform.opentargets.org/target/ENSG00000141469/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10918","ensembl":"ENSG00000141469","uniprot":"Q13336","entrez":"6563","biology":"Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes. Location: Cell membrane; Basolateral cell membrane (UniProt). Locus 18q12.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/slc14a1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}