{"entity":{"id":"slc22a3","kind":"target","name":"SLC22A3","aka":["solute carrier family 22 member 3","Solute carrier family 22 member 3","OCT3"],"tldr":"SLC22A3 (Solute carrier family 22 member 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10967"},{"label":"UniProt O75751","url":"https://www.uniprot.org/uniprotkb/O75751/entry"},{"label":"NCBI Gene 6581","url":"https://www.ncbi.nlm.nih.gov/gene/6581"},{"label":"Ensembl ENSG00000146477","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000146477"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC22A3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10967","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O75751","url":"https://www.uniprot.org/uniprotkb/O75751/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000146477","url":"https://platform.opentargets.org/target/ENSG00000146477/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:10967","ensembl":"ENSG00000146477","uniprot":"O75751","entrez":"6581","biology":"Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow. Location: Cell membrane; Apical cell membrane; Basolateral cell membrane; Mitochondrion membrane (UniProt). Locus 6q25.3 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.54 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/slc22a3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}