{"entity":{"id":"slc34a2","kind":"target","name":"SLC34A2","aka":["solute carrier family 34 member 2","Sodium-dependent phosphate transport protein 2B","NAPI-3B","NaPi-2b","NPTIIb","NaPi2b","NAPI-IIb"],"tldr":"SLC34A2 (Sodium-dependent phosphate transport protein 2B) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Lung cancer, Colorectal cancer, Non-small-cell lung cancer and 1 more.","summary":"Involved in actively transporting phosphate into cells via Na(+) cotransport.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes clinical 0.15, literature 0.96, genetic association 0.48, somatic mutation 0.86, animal model 0.28). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Colorectal Adenocarcinoma, Lung Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11020","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11020"},{"label":"UniProt O95436","url":"https://www.uniprot.org/uniprotkb/O95436/entry"},{"label":"NCBI Gene 10568","url":"https://www.ncbi.nlm.nih.gov/gene/10568"},{"label":"Ensembl ENSG00000157765","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157765"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","colorectal","nsclc","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.15; IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC34A2","role":["drug-target","oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11020","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11020","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95436","url":"https://www.uniprot.org/uniprotkb/O95436/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000157765","url":"https://platform.opentargets.org/target/ENSG00000157765/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.57, lung cancer 0.60 (GraphQL API, CC0)"},{"label":"IntOGen SLC34A2","url":"https://www.intogen.org/search?gene=SLC34A2","note":"driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11020","ensembl":"ENSG00000157765","uniprot":"O95436","entrez":"10568","biology":"Involved in actively transporting phosphate into cells via Na(+) cotransport. Location: Apical cell membrane (UniProt). Locus 4p15.2 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)","Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)","Non-small-cell lung cancer: Open Targets association 0.57 with non-small cell lung carcinoma (MONDO_0005233); IntOGen driver in 1 cohort (LUAD)","Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/slc34a2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}