{"entity":{"id":"slc45a2","kind":"target","name":"SLC45A2","aka":["solute carrier family 45 member 2","Membrane-associated transporter protein","AIM-1","OCA4"],"tldr":"SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.","summary":"Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.90, animal model 0.47, genetic association 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16472","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16472"},{"label":"UniProt Q9UMX9","url":"https://www.uniprot.org/uniprotkb/Q9UMX9/entry"},{"label":"NCBI Gene 51151","url":"https://www.ncbi.nlm.nih.gov/gene/51151"},{"label":"Ensembl ENSG00000164175","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164175"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","melanoma","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC45A2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16472","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16472","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UMX9","url":"https://www.uniprot.org/uniprotkb/Q9UMX9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164175","url":"https://platform.opentargets.org/target/ENSG00000164175/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.59, basal cell carcinoma 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:16472","ensembl":"ENSG00000164175","uniprot":"Q9UMX9","entrez":"51151","biology":"Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralisation that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. Location: Melanosome membrane (UniProt). Locus 5p13.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)","Basal cell carcinoma: Open Targets association 0.51 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"other","prevalence":[]},"route":"/targets/slc45a2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}