{"entity":{"id":"slc67a1","kind":"target","name":"SLC67A1","aka":["solute carrier family 67 member 1","Solute carrier family 67 member A1","BWR1A","TSSC5","IMPT1","ORCTL2","BWSCR1A","SLC22A18","SLC22A1L"],"tldr":"SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes genetic literature 0.38, affected pathway 0.76, literature 0.89, genetic association 0.09, somatic mutation 0.71, animal model 0.35).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10964","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10964"},{"label":"UniProt Q96BI1","url":"https://www.uniprot.org/uniprotkb/Q96BI1/entry"},{"label":"NCBI Gene 5002","url":"https://www.ncbi.nlm.nih.gov/gene/5002"},{"label":"Ensembl ENSG00000110628","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110628"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC67A1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10964","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10964","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96BI1","url":"https://www.uniprot.org/uniprotkb/Q96BI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110628","url":"https://platform.opentargets.org/target/ENSG00000110628/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10964","ensembl":"ENSG00000110628","uniprot":"Q96BI1","entrez":"5002","biology":"May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism. Location: Apical cell membrane (UniProt). Locus 11p15.4 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/slc67a1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}