{"entity":{"id":"slc6a2","kind":"target","name":"SLC6A2","aka":["solute carrier family 6 member 2","Sodium-dependent noradrenaline transporter","NET1","NAT1","SLC6A5"],"tldr":"SLC6A2 (Sodium-dependent noradrenaline transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.","summary":"Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signalling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.23, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11048","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11048"},{"label":"UniProt P23975","url":"https://www.uniprot.org/uniprotkb/P23975/entry"},{"label":"NCBI Gene 6530","url":"https://www.ncbi.nlm.nih.gov/gene/6530"},{"label":"Ensembl ENSG00000103546","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103546"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC6A2","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11048","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11048","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23975","url":"https://www.uniprot.org/uniprotkb/P23975/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000103546","url":"https://platform.opentargets.org/target/ENSG00000103546/associations","note":"association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:11048","ensembl":"ENSG00000103546","uniprot":"P23975","entrez":"6530","biology":"Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signalling neurotransmitter in the autonomic sympathetic nervous system. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis. Can also mediate sodium- and chloride-dependent transport of dopamine. Location: Cell membrane; Cell projection, axon; Synapse, synaptosome (UniProt). Locus 16q12.2 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.58 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"other","prevalence":[]},"route":"/targets/slc6a2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}