{"entity":{"id":"slc6a3","kind":"target","name":"SLC6A3","aka":["solute carrier family 6 member 3","Sodium-dependent dopamine transporter","DAT1"],"tldr":"SLC6A3 (Sodium-dependent dopamine transporter) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signalling.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.83, animal model 0.53, genetic association 0.00, clinical 0.88).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11049","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11049"},{"label":"UniProt Q01959","url":"https://www.uniprot.org/uniprotkb/Q01959/entry"},{"label":"NCBI Gene 6531","url":"https://www.ncbi.nlm.nih.gov/gene/6531"},{"label":"Ensembl ENSG00000142319","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142319"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.88. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SLC6A3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11049","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11049","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q01959","url":"https://www.uniprot.org/uniprotkb/Q01959/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000142319","url":"https://platform.opentargets.org/target/ENSG00000142319/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11049","ensembl":"ENSG00000142319","uniprot":"Q01959","entrez":"6531","biology":"Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signalling. Location: Cell membrane; Cell projection, neuron projection; Cell projection, axon (UniProt). Locus 5p15.33 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/slc6a3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}