{"entity":{"id":"slotman-pci-es-sclc","kind":"trial","name":"EORTC 08993 (Slotman): prophylactic cranial irradiation in extensive-stage small-cell lung cancer","aka":[],"tldr":"Slotman's trial showed that irradiating the brain before metastases appear cuts symptomatic brain metastases and lengthens survival in extensive-stage small-cell lung cancer, though a later Japanese trial with MRI screening did not confirm the survival gain.","summary":"EORTC 08993 randomised 286 patients with extensive-stage small-cell lung cancer who had responded to chemotherapy to prophylactic cranial irradiation or observation. Symptomatic brain metastases within a year fell from 40.4 to 14.6 percent and one-year survival rose from 13.3 to 27.1 percent (Slotman and colleagues, New England Journal of Medicine 2007). Patients were not required to have brain imaging before entry; Takahashi's 2017 trial with MRI surveillance found no survival benefit, so practice now varies.","status":"positive","asOf":"2026-09-17","links":[{"label":"NEJM 2007","url":"https://doi.org/10.1056/NEJMoa071780"}],"tags":["radiation-wave4"],"related":[],"cancers":["sclc"],"sections":[],"technologies":["prophylactic-cranial-irradiation"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["wbrt"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Extensive-stage small-cell lung cancer responding to chemotherapy: prophylactic cranial irradiation versus observation","sponsor":"EORTC","result":"Symptomatic brain metastases at 1 year 14.6% vs 40.4%; 1-year survival 27.1% vs 13.3%.","yearReported":2007,"enrolled":286,"outcomes":[{"endpoint":"Symptomatic brain metastases within 1 year","primary":true,"unit":"%","arms":[{"name":"Prophylactic cranial irradiation","n":143,"value":14.6},{"name":"Observation","n":143,"value":40.4}]}]},"route":"/trials/slotman-pci-es-sclc/","neighbours":{"cancer":[{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"}],"technology":[{"id":"prophylactic-cranial-irradiation","kind":"technology","name":"Prophylactic cranial irradiation vs MRI surveillance","route":"/technologies/prophylactic-cranial-irradiation/"}],"term":[{"id":"wbrt","kind":"term","name":"Whole-brain radiotherapy (WBRT)","route":"/terms/wbrt/"}]}}