{"entity":{"id":"slv-324","kind":"drug","name":"SLV-324","aka":[],"tldr":"SLV-324 is an experimental antibody-drug conjugate from Solve Therapeutics, in phase 1 trials for metastatic solid tumours.","summary":"SLV-324 is an antibody-drug conjugate from Solve Therapeutics. An antibody-drug conjugate combining a selective targeting antibody, the CloakLink linker and a potent cytotoxic payload, aimed at a membrane receptor protein on solid tumours that the company has not named (distinct from SLV-154's). Its furthest stage is phase 1, for metastatic solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1 NCT07108114 recruiting. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Solve Therapeutics: solvetx.com","url":"https://solvetx.com/"},{"label":"Solve Therapeutics: clinicaltrials.gov","url":"https://clinicaltrials.gov/study/NCT07108114"},{"label":"ClinicalTrials.gov: trials of SLV-324","url":"https://clinicaltrials.gov/search?intr=SLV-324"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["solve-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07108114"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"SLV-324","modality":"Antibody-drug conjugate","mechanism":"An antibody-drug conjugate combining a selective targeting antibody, the CloakLink linker and a potent cytotoxic payload, aimed at a membrane receptor protein on solid tumours that the company has not named (distinct from SLV-154's).","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/slv-324/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"company":[{"id":"solve-therapeutics","kind":"company","name":"Solve Therapeutics","route":"/companies/solve-therapeutics/"}],"trial":[{"id":"nct07108114","kind":"trial","name":"SLV-324 Treatment of Metastatic Solid Tumors","route":"/trials/nct07108114/"}]}}