{"entity":{"id":"smad7","kind":"target","name":"SMAD7","aka":["SMAD family member 7","MADH8","MADH7"],"tldr":"SMAD7 (SMAD family member 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.","summary":"Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.77).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6773","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6773"},{"label":"UniProt O15105","url":"https://www.uniprot.org/uniprotkb/O15105/entry"},{"label":"NCBI Gene 4092","url":"https://www.ncbi.nlm.nih.gov/gene/4092"},{"label":"Ensembl ENSG00000101665","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101665"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SMAD7","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6773","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6773","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15105","url":"https://www.uniprot.org/uniprotkb/O15105/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000101665","url":"https://platform.opentargets.org/target/ENSG00000101665/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0)"}],"hgnc":"HGNC:6773","ensembl":"ENSG00000101665","uniprot":"O15105","entrez":"4092","biology":"Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Location: Nucleus; Cytoplasm (UniProt). Locus 18q21.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/smad7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}