{"entity":{"id":"smarca2","kind":"target","name":"SMARCA2","aka":["SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2","BAF190","hSNF2a","hBRM","Sth1p","SNF2LA","SNF2","SWI2","SNF2L2"],"tldr":"SMARCA2 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Salivary gland cancers.","summary":"ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants. IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Salivary Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11098"},{"label":"UniProt P51531","url":"https://www.uniprot.org/uniprotkb/P51531/entry"},{"label":"NCBI Gene 6595","url":"https://www.ncbi.nlm.nih.gov/gene/6595"},{"label":"Ensembl ENSG00000080503","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000080503"}],"tags":["cancer-genes-wave"],"related":["civic","intogen"],"cancers":["salivary-gland"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["swi-snf-chromatin"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SMARCA2","role":["oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11098","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11098","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P51531","url":"https://www.uniprot.org/uniprotkb/P51531/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SMARCA2","url":"https://civicdb.org/features/5354","note":"2 evidence items, 0 assertions, 2 variants; diseases:  (GraphQL API, CC0)"},{"label":"IntOGen SMARCA2","url":"https://www.intogen.org/search?gene=SMARCA2","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11098","ensembl":"ENSG00000080503","uniprot":"P51531","entrez":"6595","biology":"ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. Location: Nucleus (UniProt). Locus 9p24.3 (HGNC).","whereFound":["Salivary gland cancers: IntOGen driver in 1 cohort (SACA)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/smarca2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"salivary-gland","kind":"cancer","name":"Salivary gland cancers","route":"/cancers/salivary-gland/"}],"pathway":[{"id":"swi-snf-chromatin","kind":"pathway","name":"SWI/SNF chromatin remodelling","route":"/pathways/swi-snf-chromatin/"}]}}