{"entity":{"id":"smarce1","kind":"target","name":"SMARCE1","aka":["SWI/SNF related BAF chromatin remodeling complex subunit E1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1","BAF57"],"tldr":"SMARCE1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Meningioma.","summary":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.02, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11109","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11109"},{"label":"UniProt Q969G3","url":"https://www.uniprot.org/uniprotkb/Q969G3/entry"},{"label":"NCBI Gene 6605","url":"https://www.ncbi.nlm.nih.gov/gene/6605"},{"label":"Ensembl ENSG00000073584","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073584"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["meningioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SMARCE1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11109","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11109","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q969G3","url":"https://www.uniprot.org/uniprotkb/Q969G3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000073584","url":"https://platform.opentargets.org/target/ENSG00000073584/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: meningioma 0.79 (GraphQL API, CC0)"}],"hgnc":"HGNC:11109","ensembl":"ENSG00000073584","uniprot":"Q969G3","entrez":"6605","biology":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). Location: Nucleus (UniProt). Locus 17q21.2 (HGNC).","whereFound":["Meningioma: Open Targets association 0.79 with meningioma (MONDO_0016642)"],"targetClass":"other","prevalence":[]},"route":"/targets/smarce1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"meningioma","kind":"cancer","name":"Meningioma","route":"/cancers/meningioma/"}]}}