{"entity":{"id":"snap25","kind":"target","name":"SNAP25","aka":["synaptosome associated protein 25","Synaptosomal-associated protein 25","SNAP-25","RIC-4","RIC4","SEC9","bA416N4.2","dJ1068F16.2"],"tldr":"SNAP25 (Synaptosomal-associated protein 25) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.84, animal model 0.46, genetic association 0.00, clinical 0.78).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11132","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11132"},{"label":"UniProt P60880","url":"https://www.uniprot.org/uniprotkb/P60880/entry"},{"label":"NCBI Gene 6616","url":"https://www.ncbi.nlm.nih.gov/gene/6616"},{"label":"Ensembl ENSG00000132639","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132639"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.78. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SNAP25","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11132","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11132","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P60880","url":"https://www.uniprot.org/uniprotkb/P60880/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000132639","url":"https://platform.opentargets.org/target/ENSG00000132639/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11132","ensembl":"ENSG00000132639","uniprot":"P60880","entrez":"6616","biology":"t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. Location: Cytoplasm, perinuclear region; Cell membrane; Synapse, synaptosome; Photoreceptor inner segment (UniProt). Locus 20p12.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/snap25/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}