{"entity":{"id":"sncaip","kind":"target","name":"SNCAIP","aka":["synuclein alpha interacting protein","Synphilin-1","SYPH1"],"tldr":"SNCAIP (Synphilin-1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11139","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11139"},{"label":"UniProt Q9Y6H5","url":"https://www.uniprot.org/uniprotkb/Q9Y6H5/entry"},{"label":"NCBI Gene 9627","url":"https://www.ncbi.nlm.nih.gov/gene/9627"},{"label":"Ensembl ENSG00000064692","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000064692"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Medulloblastoma Non-WNT/non-SHH Group 4."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SNCAIP","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11139","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11139","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6H5","url":"https://www.uniprot.org/uniprotkb/Q9Y6H5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SNCAIP","url":"https://civicdb.org/features/7608","note":"1 evidence items, 0 assertions, 1 variants; diseases: Medulloblastoma Non-WNT/non-SHH Group 4 (GraphQL API, CC0)"}],"hgnc":"HGNC:11139","ensembl":"ENSG00000064692","uniprot":"Q9Y6H5","entrez":"9627","biology":"Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. Location: Cytoplasm (UniProt). Locus 5q23.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sncaip/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}