{"entity":{"id":"snd1","kind":"target","name":"SND1","aka":["staphylococcal nuclease and tudor domain containing 1","Staphylococcal nuclease domain-containing protein 1","TDRD11","p100"],"tldr":"SND1 (Staphylococcal nuclease domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Lung cancer and 3 more.","summary":"Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor.\n\nOpen Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes affected pathway 0.89, literature 0.98, genetic association 0.03, somatic mutation 0.83, animal model 0.38). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Cervical Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30646"},{"label":"UniProt Q7KZF4","url":"https://www.uniprot.org/uniprotkb/Q7KZF4/entry"},{"label":"NCBI Gene 27044","url":"https://www.ncbi.nlm.nih.gov/gene/27044"},{"label":"Ensembl ENSG00000197157","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197157"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["cervical","breast-cancer","lung-cancer","colorectal","non-hodgkin-lymphoma","leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SND1","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30646","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30646","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7KZF4","url":"https://www.uniprot.org/uniprotkb/Q7KZF4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000197157","url":"https://platform.opentargets.org/target/ENSG00000197157/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.52, non-Hodgkin lymphoma 0.52, breast cancer 0.56, lung cancer 0.54, leukaemia 0.51 (GraphQL API, CC0)"},{"label":"IntOGen SND1","url":"https://www.intogen.org/search?gene=SND1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30646","ensembl":"ENSG00000197157","uniprot":"Q7KZF4","entrez":"27044","biology":"Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. Location: Cytoplasm; Nucleus; Melanosome (UniProt). Locus 7q32.1 (HGNC).","whereFound":["Cervical cancer: IntOGen driver in 1 cohort (CESC)","Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)","Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/snd1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}