{"entity":{"id":"snw1","kind":"target","name":"SNW1","aka":["SNW domain containing 1","SNW domain-containing protein 1","NCoA-62","Prp45","PRPF45","Bx42","SKIP1","FUN20","SKIIP"],"tldr":"SNW1 (SNW domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.39, affected pathway 0.95, genetic association 0.03).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16696","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16696"},{"label":"UniProt Q13573","url":"https://www.uniprot.org/uniprotkb/Q13573/entry"},{"label":"NCBI Gene 22938","url":"https://www.ncbi.nlm.nih.gov/gene/22938"},{"label":"Ensembl ENSG00000100603","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100603"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SNW1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16696","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16696","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13573","url":"https://www.uniprot.org/uniprotkb/Q13573/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100603","url":"https://platform.opentargets.org/target/ENSG00000100603/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"hgnc":"HGNC:16696","ensembl":"ENSG00000100603","uniprot":"Q13573","entrez":"22938","biology":"Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/snw1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}