{"entity":{"id":"snx29","kind":"target","name":"SNX29","aka":["sorting nexin 29","Sorting nexin-29","FLJ12363","RUNDC2A"],"tldr":"SNX29 (Sorting nexin-29) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer and Small intestine cancer.","summary":"UniProt has no function text for Q8TEQ0; HGNC names it \"sorting nexin 29\".\n\nIntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Small Intestinal Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30542","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30542"},{"label":"UniProt Q8TEQ0","url":"https://www.uniprot.org/uniprotkb/Q8TEQ0/entry"},{"label":"NCBI Gene 92017","url":"https://www.ncbi.nlm.nih.gov/gene/92017"},{"label":"Ensembl ENSG00000048471","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000048471"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","small-bowel"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SNX29","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:30542","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30542","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8TEQ0","url":"https://www.uniprot.org/uniprotkb/Q8TEQ0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SNX29","url":"https://www.intogen.org/search?gene=SNX29","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:30542","ensembl":"ENSG00000048471","uniprot":"Q8TEQ0","entrez":"92017","biology":"UniProt has no function text for Q8TEQ0; HGNC names it \"sorting nexin 29\". Locus 16p13.13-p13.12 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Small intestine cancer: IntOGen driver in 1 cohort (SIC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/snx29/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"small-bowel","kind":"cancer","name":"Small intestine cancer (small bowel adenocarcinoma)","route":"/cancers/small-bowel/"}]}}