{"entity":{"id":"sorcs3","kind":"target","name":"SORCS3","aka":["sortilin related VPS10 domain containing receptor 3","VPS10 domain-containing receptor SorCS3","KIAA1059","SORCS"],"tldr":"SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.63).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16699","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16699"},{"label":"UniProt Q9UPU3","url":"https://www.uniprot.org/uniprotkb/Q9UPU3/entry"},{"label":"NCBI Gene 22986","url":"https://www.ncbi.nlm.nih.gov/gene/22986"},{"label":"Ensembl ENSG00000156395","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156395"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SORCS3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16699","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16699","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UPU3","url":"https://www.uniprot.org/uniprotkb/Q9UPU3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156395","url":"https://platform.opentargets.org/target/ENSG00000156395/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:16699","ensembl":"ENSG00000156395","uniprot":"Q9UPU3","entrez":"22986","biology":"Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density. Location: Cell membrane; Synaptic cell membrane; Postsynaptic density (UniProt). Locus 10q25.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sorcs3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}