{"entity":{"id":"sos1","kind":"target","name":"SOS1","aka":["SOS Ras/Rac guanine nucleotide exchange factor 1","Son of sevenless homolog 1","GF1","GINGF"],"tldr":"SOS1 (Son of sevenless homolog 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Skin cancer, Breast cancer and 1 more.","summary":"Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes affected pathway 0.83, literature 0.94, genetic association 0.00, somatic mutation 0.91, animal model 0.38). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11187","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11187"},{"label":"UniProt Q07889","url":"https://www.uniprot.org/uniprotkb/Q07889/entry"},{"label":"NCBI Gene 6654","url":"https://www.ncbi.nlm.nih.gov/gene/6654"},{"label":"Ensembl ENSG00000115904","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115904"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["endometrial","skin-cancer","breast-cancer","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["ras-mapk"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SOS1","role":["oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11187","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11187","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q07889","url":"https://www.uniprot.org/uniprotkb/Q07889/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SOS1","url":"https://civicdb.org/features/5409","note":"1 evidence items, 0 assertions, 1 variants; diseases:  (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000115904","url":"https://platform.opentargets.org/target/ENSG00000115904/associations","note":"association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: gastric cancer 0.51, endometrial cancer 0.53, skin cancer 0.56, breast cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen SOS1","url":"https://www.intogen.org/search?gene=SOS1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11187","ensembl":"ENSG00000115904","uniprot":"Q07889","entrez":"6654","biology":"Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. Locus 2p22.1 (HGNC).","whereFound":["Endometrial cancer: Open Targets association 0.53 with endometrial cancer (MONDO_0011962); IntOGen driver in 1 cohort (UCEC)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/sos1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"ras-mapk","kind":"pathway","name":"RAS / RAF / MEK / ERK (MAPK)","route":"/pathways/ras-mapk/"}]}}