{"entity":{"id":"sovilnesib","kind":"drug","name":"Sovilnesib","aka":["AMG650","AMG-650"],"tldr":"Sovilnesib is an experimental pill from Volastra Therapeutics, in phase 1 trials for high-grade serous ovarian cancer.","summary":"Sovilnesib (AMG 650) is a small molecule, oral from Volastra Therapeutics. Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Volastra in-licensed it from Amgen in February 2023. NCT04293094 began in 2020 as Amgen's first study of AMG 650 in advanced solid tumours and is completed; NCT06084416 is recruiting people with high-grade serous ovarian, fallopian tube or primary peritoneal cancer. The company reports an FDA Fast Track designation in platinum-resistant high-grade serous ovarian cancer. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"Volastra Therapeutics pipeline","url":"https://www.volastratx.com/pipeline/"},{"label":"Volastra partnerships and deals","url":"https://www.volastratx.com/partnerships-and-deals/"},{"label":"ClinicalTrials.gov NCT06084416","url":"https://clinicaltrials.gov/study/NCT06084416"},{"label":"ClinicalTrials.gov NCT04293094","url":"https://clinicaltrials.gov/study/NCT04293094"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["high-grade-serous-ovarian-cancer"],"sections":[],"technologies":[],"targets":["kif18a"],"drugs":[],"companies":["volastra-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06084416","nct04293094"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"AMG 650","modality":"Small molecule, oral","mechanism":"Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/sovilnesib/","neighbours":{"cancer":[{"id":"high-grade-serous-ovarian-cancer","kind":"cancer","name":"High-grade serous ovarian cancer","route":"/cancers/high-grade-serous-ovarian-cancer/"}],"target":[{"id":"kif18a","kind":"target","name":"KIF18A","route":"/targets/kif18a/"}],"company":[{"id":"volastra-therapeutics","kind":"company","name":"Volastra Therapeutics","route":"/companies/volastra-therapeutics/"}],"trial":[{"id":"nct06084416","kind":"trial","name":"A Study of Sovilnesib in Subjects With Ovarian Cancer","route":"/trials/nct06084416/"},{"id":"nct04293094","kind":"trial","name":"Study of AMG 650 in Adult Participants With Advanced Solid Tumors","route":"/trials/nct04293094/"}]}}