{"entity":{"id":"sox17","kind":"target","name":"SOX17","aka":["SRY-box transcription factor 17","Transcription factor SOX-17"],"tldr":"SOX17 (Transcription factor SOX-17) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18122","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18122"},{"label":"UniProt Q9H6I2","url":"https://www.uniprot.org/uniprotkb/Q9H6I2/entry"},{"label":"NCBI Gene 64321","url":"https://www.ncbi.nlm.nih.gov/gene/64321"},{"label":"Ensembl ENSG00000164736","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164736"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SOX17","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18122","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18122","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H6I2","url":"https://www.uniprot.org/uniprotkb/Q9H6I2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SOX17","url":"https://www.intogen.org/search?gene=SOX17","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18122","ensembl":"ENSG00000164736","uniprot":"Q9H6I2","entrez":"64321","biology":"Acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signalling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/sox17/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}