{"entity":{"id":"sox2","kind":"target","name":"SOX2","aka":["SRY-box transcription factor 2","Transcription factor SOX-2"],"tldr":"SOX2 (Transcription factor SOX-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Skin cancer and Lung cancer.","summary":"Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.62, animal model 0.69, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11195","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11195"},{"label":"UniProt P48431","url":"https://www.uniprot.org/uniprotkb/P48431/entry"},{"label":"NCBI Gene 6657","url":"https://www.ncbi.nlm.nih.gov/gene/6657"},{"label":"Ensembl ENSG00000181449","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181449"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","skin-cancer","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["lineage-plasticity-neuroendocrine"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SOX2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11195","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11195","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P48431","url":"https://www.uniprot.org/uniprotkb/P48431/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000181449","url":"https://platform.opentargets.org/target/ENSG00000181449/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: colorectal cancer 0.55, skin cancer 0.53, lung cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:11195","ensembl":"ENSG00000181449","uniprot":"P48431","entrez":"6657","biology":"Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. Location: Nucleus speckle; Cytoplasm; Nucleus (UniProt). Locus 3q26.33 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/sox2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"lineage-plasticity-neuroendocrine","kind":"pathway","name":"Lineage plasticity & neuroendocrine transformation","route":"/pathways/lineage-plasticity-neuroendocrine/"}]}}