{"entity":{"id":"sox21","kind":"target","name":"SOX21","aka":["SRY-box transcription factor 21","Transcription factor SOX-21","SOX25"],"tldr":"SOX21 (Transcription factor SOX-21) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.","summary":"May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. May play a role in ameloblast differentiation.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11197","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11197"},{"label":"UniProt Q9Y651","url":"https://www.uniprot.org/uniprotkb/Q9Y651/entry"},{"label":"NCBI Gene 11166","url":"https://www.ncbi.nlm.nih.gov/gene/11166"},{"label":"Ensembl ENSG00000125285","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125285"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SOX21","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:11197","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11197","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y651","url":"https://www.uniprot.org/uniprotkb/Q9Y651/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SOX21","url":"https://www.intogen.org/search?gene=SOX21","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11197","ensembl":"ENSG00000125285","uniprot":"Q9Y651","entrez":"11166","biology":"May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells. May play a role in ameloblast differentiation. Location: Nucleus (UniProt). Locus 13q32.1 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/sox21/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}