{"entity":{"id":"sphk1","kind":"target","name":"SPHK1","aka":["sphingosine kinase 1","Sphingosine kinase 1"],"tldr":"SPHK1 (Sphingosine kinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Cervical cancer.","summary":"Catalyses the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11240","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11240"},{"label":"UniProt Q9NYA1","url":"https://www.uniprot.org/uniprotkb/Q9NYA1/entry"},{"label":"NCBI Gene 8877","url":"https://www.ncbi.nlm.nih.gov/gene/8877"},{"label":"Ensembl ENSG00000176170","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000176170"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["cervical"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SPHK1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11240","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11240","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NYA1","url":"https://www.uniprot.org/uniprotkb/Q9NYA1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene SPHK1","url":"https://civicdb.org/features/7041","note":"1 evidence items, 0 assertions, 1 variants; diseases: Cervical Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:11240","ensembl":"ENSG00000176170","uniprot":"Q9NYA1","entrez":"8877","biology":"Catalyses the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signalling leading to IL17 secretion. In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signalling pathway. Location: Cytoplasm; Nucleus; Cell membrane; Endosome membrane (UniProt). Locus 17q25.1 (HGNC).","whereFound":["Cervical cancer: CIViC evidence names this disease"],"targetClass":"kinase","prevalence":[]},"route":"/targets/sphk1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"}]}}