{"entity":{"id":"spry4","kind":"target","name":"SPRY4","aka":["sprouty RTK signaling antagonist 4"],"tldr":"SPRY4 is a feedback brake on growth-factor signalling that the MAPK pathway switches on, so its expression is a read-out of how active that pathway is.","summary":"SPRY4, like SPRY2, is a Sprouty family feedback inhibitor: UniProt describes it as suppressing receptor-driven MAPK signalling upstream of Ras and RAF1. Because the pathway induces its own inhibitors, SPRY2, SPRY4 and the DUSP phosphatases are the transcriptional output genes used to infer MAPK activity from expression, and they fall when a MEK inhibitor works.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:15533","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15533"},{"label":"UniProt Q9C004","url":"https://www.uniprot.org/uniprotkb/Q9C004/entry"}],"tags":["cansim-terms"],"related":["spry2"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["ras-mapk"],"terms":["co-amplification","cancer-ai-vocabulary","pathway-activation-state"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"SPRY4","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:15533","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15533","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt Q9C004","url":"https://www.uniprot.org/uniprotkb/Q9C004/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:15533","ensembl":"ENSG00000187678","uniprot":"Q9C004","entrez":"81848","biology":"Suppresses insulin receptor and EGFR-transduced MAPK signalling, probably by impairing GTP-Ras formation; inhibits Ras-independent activation of RAF1 (UniProt Q9C004).","whereFound":["Locus 5q31.3 (HGNC)."],"targetClass":"other","prevalence":[]},"route":"/targets/spry4/","neighbours":{"target":[{"id":"spry2","kind":"target","name":"SPRY2","route":"/targets/spry2/"}],"pathway":[{"id":"ras-mapk","kind":"pathway","name":"RAS / RAF / MEK / ERK (MAPK)","route":"/pathways/ras-mapk/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"pathway-activation-state","kind":"term","name":"Pathway activation state (phosphosignalling)","route":"/terms/pathway-activation-state/"}]}}