{"entity":{"id":"sptbn1","kind":"target","name":"SPTBN1","aka":["spectrin beta, non-erythrocytic 1","Spectrin beta chain, non-erythrocytic 1"],"tldr":"SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.95, animal model 0.51, genetic association 0.28).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11275","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11275"},{"label":"UniProt Q01082","url":"https://www.uniprot.org/uniprotkb/Q01082/entry"},{"label":"NCBI Gene 6711","url":"https://www.ncbi.nlm.nih.gov/gene/6711"},{"label":"Ensembl ENSG00000115306","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115306"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SPTBN1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11275","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11275","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q01082","url":"https://www.uniprot.org/uniprotkb/Q01082/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000115306","url":"https://platform.opentargets.org/target/ENSG00000115306/associations","note":"association with cancer (MONDO_0004992) 0.65;  (GraphQL API, CC0)"}],"hgnc":"HGNC:11275","ensembl":"ENSG00000115306","uniprot":"Q01082","entrez":"6711","biology":"Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Location: Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, M line; Cytoplasm, cytosol; Cell membrane (UniProt). Locus 2p16.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/sptbn1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}