{"entity":{"id":"srd5a3","kind":"target","name":"SRD5A3","aka":["steroid 5 alpha-reductase 3","Polyprenal reductase","FLJ13352","SRD5A2L","SRD5A2L1"],"tldr":"SRD5A3 (Polyprenal reductase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.","summary":"Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.00, clinical 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25812","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25812"},{"label":"UniProt Q9H8P0","url":"https://www.uniprot.org/uniprotkb/Q9H8P0/entry"},{"label":"NCBI Gene 79644","url":"https://www.ncbi.nlm.nih.gov/gene/79644"},{"label":"Ensembl ENSG00000128039","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128039"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SRD5A3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:25812","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25812","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H8P0","url":"https://www.uniprot.org/uniprotkb/Q9H8P0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000128039","url":"https://platform.opentargets.org/target/ENSG00000128039/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: prostate cancer 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:25812","ensembl":"ENSG00000128039","uniprot":"Q9H8P0","entrez":"79644","biology":"Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). Location: Endoplasmic reticulum membrane (UniProt). Locus 4q12 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/srd5a3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}