{"entity":{"id":"srgap3","kind":"target","name":"SRGAP3","aka":["SLIT-ROBO Rho GTPase activating protein 3","SLIT-ROBO Rho GTPase-activating protein 3","KIAA0411","MEGAP","ARHGAP14","SRGAP2"],"tldr":"SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.","summary":"GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19744","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19744"},{"label":"UniProt O43295","url":"https://www.uniprot.org/uniprotkb/O43295/entry"},{"label":"NCBI Gene 9901","url":"https://www.ncbi.nlm.nih.gov/gene/9901"},{"label":"Ensembl ENSG00000196220","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196220"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SRGAP3","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19744","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19744","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43295","url":"https://www.uniprot.org/uniprotkb/O43295/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen SRGAP3","url":"https://www.intogen.org/search?gene=SRGAP3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:19744","ensembl":"ENSG00000196220","uniprot":"O43295","entrez":"9901","biology":"GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons. Locus 3p25.3 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/srgap3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}