{"entity":{"id":"srsf3","kind":"target","name":"SRSF3","aka":["serine and arginine rich splicing factor 3","Serine/arginine-rich splicing factor 3","SRp20","SFRS3"],"tldr":"SRSF3 (Serine/arginine-rich splicing factor 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.95).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10785"},{"label":"UniProt P84103","url":"https://www.uniprot.org/uniprotkb/P84103/entry"},{"label":"NCBI Gene 6428","url":"https://www.ncbi.nlm.nih.gov/gene/6428"},{"label":"Ensembl ENSG00000112081","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112081"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SRSF3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:10785","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10785","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P84103","url":"https://www.uniprot.org/uniprotkb/P84103/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000112081","url":"https://platform.opentargets.org/target/ENSG00000112081/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"hgnc":"HGNC:10785","ensembl":"ENSG00000112081","uniprot":"P84103","entrez":"6428","biology":"Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognises and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Location: Nucleus; Nucleus speckle; Cytoplasm (UniProt). Locus 6p21.31-p21.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/srsf3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}