{"entity":{"id":"ss18","kind":"target","name":"SS18","aka":["SS18 subunit of BAF chromatin remodeling complex","SMARCL1"],"tldr":"SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.","summary":"Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.21, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11340","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11340"},{"label":"UniProt Q15532","url":"https://www.uniprot.org/uniprotkb/Q15532/entry"},{"label":"NCBI Gene 6760","url":"https://www.ncbi.nlm.nih.gov/gene/6760"},{"label":"Ensembl ENSG00000141380","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000141380"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","synovial-sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SS18","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11340","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11340","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15532","url":"https://www.uniprot.org/uniprotkb/Q15532/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000141380","url":"https://platform.opentargets.org/target/ENSG00000141380/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: sarcoma 0.61, synovial sarcoma 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:11340","ensembl":"ENSG00000141380","uniprot":"Q15532","entrez":"6760","biology":"Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Location: Nucleus (UniProt). Locus 18q11.2 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089)","Synovial sarcoma: Open Targets association 0.53 with synovial sarcoma (MONDO_0010434)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ss18/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"synovial-sarcoma","kind":"cancer","name":"Synovial sarcoma","route":"/cancers/synovial-sarcoma/"}]}}