{"entity":{"id":"sstr1","kind":"target","name":"SSTR1","aka":["somatostatin receptor 1","Somatostatin receptor type 1"],"tldr":"SSTR1 (Somatostatin receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.","summary":"Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.85, animal model 0.36, genetic association 0.00, clinical 0.90).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11330","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11330"},{"label":"UniProt P30872","url":"https://www.uniprot.org/uniprotkb/P30872/entry"},{"label":"NCBI Gene 6751","url":"https://www.ncbi.nlm.nih.gov/gene/6751"},{"label":"Ensembl ENSG00000139874","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139874"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SSTR1","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11330","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11330","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P30872","url":"https://www.uniprot.org/uniprotkb/P30872/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000139874","url":"https://platform.opentargets.org/target/ENSG00000139874/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:11330","ensembl":"ENSG00000139874","uniprot":"P30872","entrez":"6751","biology":"Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Location: Cell membrane (UniProt). Locus 14q21.1 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.59 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"other","prevalence":[]},"route":"/targets/sstr1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}