{"entity":{"id":"sstr4","kind":"target","name":"SSTR4","aka":["somatostatin receptor 4","Somatostatin receptor type 4"],"tldr":"SSTR4 (Somatostatin receptor type 4) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.","summary":"Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.59, clinical 0.90).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11333","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11333"},{"label":"UniProt P31391","url":"https://www.uniprot.org/uniprotkb/P31391/entry"},{"label":"NCBI Gene 6754","url":"https://www.ncbi.nlm.nih.gov/gene/6754"},{"label":"Ensembl ENSG00000132671","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132671"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"SSTR4","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:11333","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11333","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31391","url":"https://www.uniprot.org/uniprotkb/P31391/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000132671","url":"https://platform.opentargets.org/target/ENSG00000132671/associations","note":"association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:11333","ensembl":"ENSG00000132671","uniprot":"P31391","entrez":"6754","biology":"Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumour cells. Location: Cell membrane (UniProt). Locus 20p11.21 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.59 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"other","prevalence":[]},"route":"/targets/sstr4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}]}}