{"entity":{"id":"stat6","kind":"target","name":"STAT6","aka":["signal transducer and activator of transcription 6","Signal transducer and activator of transcription 6","D12S1644","IL-4-STAT"],"tldr":"STAT6 (Signal transducer and activator of transcription 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma and Diffuse large B-cell lymphoma.","summary":"Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signalling.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, animal model 0.31, genetic association 0.08, somatic mutation 0.89). IntOGen calls it a driver in 4 cohorts (4 activating, 0 loss-of-function), covering Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11368","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11368"},{"label":"UniProt P42226","url":"https://www.uniprot.org/uniprotkb/P42226/entry"},{"label":"NCBI Gene 6778","url":"https://www.ncbi.nlm.nih.gov/gene/6778"},{"label":"Ensembl ENSG00000166888","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166888"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 4 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"STAT6","role":["oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11368","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11368","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P42226","url":"https://www.uniprot.org/uniprotkb/P42226/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene STAT6","url":"https://civicdb.org/features/5520","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000166888","url":"https://platform.opentargets.org/target/ENSG00000166888/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.51, non-Hodgkin lymphoma 0.65 (GraphQL API, CC0)"},{"label":"IntOGen STAT6","url":"https://www.intogen.org/search?gene=STAT6","note":"driver in 4 cohorts (Act 4, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11368","ensembl":"ENSG00000166888","uniprot":"P42226","entrez":"6778","biology":"Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signalling. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.65 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 2 cohorts (MLYM, NHL)","Diffuse large B-cell lymphoma: Open Targets association 0.51 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/stat6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}