{"entity":{"id":"stmn1","kind":"target","name":"STMN1","aka":["stathmin 1","Stathmin","OP18","PR22","PP19","PP17","Lag","FLJ32206","LAP18","C1orf215"],"tldr":"STMN1 (Stathmin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer.","summary":"Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6510","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6510"},{"label":"UniProt P16949","url":"https://www.uniprot.org/uniprotkb/P16949/entry"},{"label":"NCBI Gene 3925","url":"https://www.ncbi.nlm.nih.gov/gene/3925"},{"label":"Ensembl ENSG00000117632","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000117632"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"STMN1","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6510","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6510","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P16949","url":"https://www.uniprot.org/uniprotkb/P16949/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene STMN1","url":"https://civicdb.org/features/3255","note":"1 evidence items, 0 assertions, 1 variants; diseases: Endometrial Carcinoma (GraphQL API, CC0)"}],"hgnc":"HGNC:6510","ensembl":"ENSG00000117632","uniprot":"P16949","entrez":"3925","biology":"Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).","whereFound":["Endometrial cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/stmn1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}