{"entity":{"id":"strn","kind":"target","name":"STRN","aka":["striatin","Striatin","PPP2R6A","STRN1"],"tldr":"STRN (Striatin) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer and Lung cancer.","summary":"Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.\n\nOpen Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes literature 0.80, affected pathway 0.91, genetic association 0.51, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11424","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11424"},{"label":"UniProt O43815","url":"https://www.uniprot.org/uniprotkb/O43815/entry"},{"label":"NCBI Gene 6801","url":"https://www.ncbi.nlm.nih.gov/gene/6801"},{"label":"Ensembl ENSG00000115808","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115808"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"STRN","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:11424","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11424","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43815","url":"https://www.uniprot.org/uniprotkb/O43815/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000115808","url":"https://platform.opentargets.org/target/ENSG00000115808/associations","note":"association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: thyroid cancer 0.54, lung cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:11424","ensembl":"ENSG00000115808","uniprot":"O43815","entrez":"6801","biology":"Calmodulin-binding scaffolding protein which is the centre of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signalling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Location: Cytoplasm; Membrane; Cell projection, dendritic spine (UniProt). Locus 2p22.2 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.54 with thyroid cancer (MONDO_0002108)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)"],"targetClass":"other","prevalence":[]},"route":"/targets/strn/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}